Researchers at Cedars-Sinai Medical Center have analyzed data from 400.000 patient cells to better understand the disease and come up with more effective treatments.

Researchers of Cedars-sinai have created a detailed molecular profile of endometriosis that will help improve treatment options for millions of women with the disease worldwide.

Published in the scientific journal Nature Genetics, the study led by Dr. Kate Lawrenson has managed to profile endometriosis using state-of-the-art methods that have allowed researchers to collect an immense amount of data from the cells of just 21 patients.

Identified the molecular differences between the main subtypes of endometriosis

“We have generated a cell atlas of endometriosis after analyzing almost 400 individual cells from these patients. We were able to identify molecular differences between the major subtypes of endometriosis, including peritoneal disease and ovarian endometrioma," says Lawrenson, who is also an associate professor in the Department of Biomedical Sciences.

Endometriosis is a chronic disease It affects about 10% of the world's female population, generally of childbearing age. In endometriosis, the endometrium implants outside its usual place, often in the ovaries, fallopian tubes, and abdominal cavity, but also in other parts of the body that are further away.

Patients can suffer a lot of pain during menstruation and ovulation, continuous pelvic pain, discomfort during sexual intercourse, infertility, and bowel and bladder dysfunction.

“Endometriosis has been an understudied disease in part due to limited cellular data that has hindered the development of effective treatments. In this study, we applied a new technology called single cell genomics, which allowed us to profile the different types of cells that contribute to disease,” explains Dr Lawrenson.

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