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Endometriosis: The Possible Pain Mechanisms

Endometriosis: possible mechanisms of pain

The definition of the origin and causes of the painful process of endometriosis remains incomplete. Clinical studies have revealed that patients with endometriosis experience complex pain, of which neuropathic pain is a part.

The main symptoms of endometriosis are infertility and pain, which can present in the form of painful rules, during or after sexual intercourse, when performing physiological needs, etc.

In endometriosis, the endometrium implants outside of its usual place. From the place where it has been implanted, it prepares each month for a possible pregnancy and responds in the same way to the hormones of the ovary.

Since the endometrium is not in place, the period stays inside the body and produces adhesions, that is, organs such as the intestines or the ovaries stick together, causing pain and infertility.

Understanding the mechanisms of pelvic pain associated with endometriosis is crucial for proper management and treatment of the disease."

Members of the Department of Obstetrics and Gynecology, Tongi Medical College, Huazhong University (China) have recently published "Expert Reviews in Molecular Medicine" their conclusions about what may be the possible pathways of pain in endometriosis.

The aim of the study is to deepen the understanding of pain induced by endometriosis to help create individualized treatments for the future.

The inflammatory process is the initiator of complex pain pathways. While pain information is being processed, multiple brain regions interact with each other through various sophisticated mechanisms that are not yet fully understood.

The pain associated with endometriosis is related to changes in the structure and function of the brain.

Pain associated with endometriosis is related to changes in brain structure and function, dysregulation of pain pathways, and increased activity in brain regions that result in hyperalgesia.

Hyperalgesia (increased sensitivity to pain with an extreme reaction to it) occurs when nerves are damaged or there are chemical changes in the nerve pathways involved in pain perception.


Endometriosis is a chronic disease that mainly affects women of reproductive age and is affected by approximately 10% of the world's female population of childbearing age.

Endometriosis produces a lot pain during menstruation and ovulation, often ongoing pelvic pain, and discomfort during intercourse. These physical discomforts are often intolerable, prevent normal life and, on some occasions, hinder or prevent pregnancy.

El main objective of endometriosis treatment It is to alleviate the symptoms of the disease, both the pain and the associated infertility, and to avoid the radical extirpation of the female reproductive system.

Treatment of endometriosis sometimes requires surgical intervention. However, endometriosis surgery should only be performed multidisciplinary teams with the experience and knowledge that guarantee maximum security possible to the patient.

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