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La adenomyosis It is a chronic, estrogen-dependent disease in which endometrial tissue appears and grows outside the uterine cavity, producing an inflammatory reaction.

Relevant aspects of adenomyosis

  • It is a benign and frequent disease but very little diagnosed or suspected.
  • The number of posts with Main MeSH "ADENOMYOSIS" is 10% that of the endometriosis.
  • Important clinical and health problem with implication in health costs, quality of life.
  • Classically post-hysterectomy diagnosis.
  • Preoperative diagnosis now possible.
  • There are ectopic endometrial glands and stroma in the thickness of the myometrium.
  • Produces a local inflammatory response.
  • There is a variable degree of hyperplasia in the adjacent myometrium.

A very important aspect that must be known is the mechanical activity of the non-pregnant uterus that in the first 10 years of a woman's reproductive life there are 10 × 10 (6) peristaltic activities (35 mm Hg) 130 × 10 (3) menstrual endometrial contractions (200-300 mm Hg).


La pathogenesis of adenomyosis It is generated by a disruption of the interface between the basal endometrium and the myometrium, producing a myometrial invasion by endometrial glands and stroma. Disruption of the endometrial-myometrial interface can be favored by a cesarean section, a myomectomy, curettage and other surgical interventions.

Adenomyosis Clinic

The clinical forms of adenomyosis can be:

  • Diffuse adenomyosis
  • Endometrial glands and stroma present throughout the endometrium
  • Focal adenomyosis
  • Endometrial glands and stroma in restricted areas of the myometrium
  • Adenomyoma
  • Cystic adenomyoma
  • Other forms

Symptoms of adenomyosis

  • In menstruation:
    • Abnormal uterine bleeding
    • Rules with heavy bleeding
    • Rules of excessive duration
    • Clot emission during menstruation
    • Spotting (abnormal bleeding) between periods
  • Pain:
  • Enlarged uterus
  • Other symptoms
    • Subfertility
    • Chronic pelvic pain

Clinical aspects

  • Abnormal uterine-tubal transport
  • Intrauterine abnormalities
  • Alteration of uterine peristalsis and sperm transport • Alteration of endometrial architecture and its function
  • Altered endometrial function
  • Aberrant endometrial metabolism
  • Alteration of the endometrial oxidative environment
  • Alteration of implantation
Dr. Francisco Carmona excellence in gynecology

Dr Francisco Carmona

Medical Director of the Women's CD gynecological clinic in Barcelona
Head of Gynecology at Hospital Clinic de Barcelona
SEUD member

    Make an appointment with Dr. Francisco Carmona

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