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Multi-resistant tumors discovered a weak point that makes them "vulnerable"

Multi-resistant tumors: discovered a weak point that makes them "vulnerable"

Spanish researchers from the National Cancer Research Center (CNIO) have discovered a new strategy to combat multi-drug resistance that some tumors generate.

The results of study, still in preclinical phases, show "why many of the usual therapies do not work in some tumors, and at the same time identify the weak point of these resistant cancers", affirms in a press release the main author of this research, Óscar Fernández- Capetillo, head of Genomic Instability Group of the CNIO.

Mutations that inactivate the function of a specific gene, FBXW7, one of the ten most frequently mutated genes in human cancers, "reduce sensitivity to the vast majority of available therapies", explain those responsible for the study.

But, "while reducing sensitivity to a good part of the available therapies, they make tumor cells vulnerable to the action of a specific type of drug that already exists: those that activate the “integrated response to stress”.

An effective antibiotic against tumor cells

Research carried out by researchers at the National Cancer Research Center has shown that the antibiotic tigecycline is toxic to cells deficient in FBXW7 by causing hyperactivation of the integrated stress response (ISR)

“Our studies, added to other recent ones, indicate that activating the integrated response to stress could be a way to overcome resistance to chemotherapy. However, much remains to be done. Which drugs are the ones that best and most activate the ISR? Which patients are the ones that would benefit the most from this strategy? Trying to answer these questions is what we intend to dedicate ourselves to in the immediate future”, the researchers conclude.


The annual gynecological check-up is a specialized medical visit that is carried out in order to prevent or diagnose and treat early pathologies that may arise throughout the different stages of a woman's life.

Scientific societies and guides clinical practice They recommend that from the age of 40 women carry out gynecological check-ups on an annual basis, in order to take care of your health and carry out prevention that can be of the greatest importance to avoid future problems.

But if you have any concerns, vaginal discomfort, period-related pain or you seem to notice changes in your breasts, make an appointment with your gynecologist as soon as possible.

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